[Estradiol benzoate test in the study of pituitary block induced by triptorelin]. / Studio dinamico del blocco ipofisario indotto dalla triptorelina, mediante test all'estradiolo benzoato.
Minerva Ginecol
; 45(4): 185-9, 1993 Apr.
Article
en It
| MEDLINE
| ID: mdl-8506068
ABSTRACT
The suppression of the positive oestradiol (E2) feed-back mechanism was studied in 21 patients during treatment with long acting GnRHa-triptorelin 3.75 mg (Ipsen-Biotech). A basal sample for FSH, LH and E2 evaluation was taken before a single administration of 2.5 mg of oestradiol benzoate (EB) i.m. at 24 and 48 hours later. The test was performed 1, 2, 3, 4, 5, 6 and 7 weeks after i.m. injection of GnRHa. The E2 concentration 24 hours after EB injection was > 400 pg/ml, able to induce, in physiological conditions, a positive feedback. In the other hand no FSH an LH rise was observed in all test after 1, 2, 3, 4, 5, 6 and 7 weeks from GnRHa administration. Our results show the absolute suppression of the positive feed-back mechanism during the treatment with a single dose of long acting tryptorelin 3.75 mg i.m., the same results were obtained until the 7th week after GnRHa administration.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hipófisis
/
Pamoato de Triptorelina
/
Estradiol
Límite:
Adult
/
Female
/
Humans
Idioma:
It
Revista:
Minerva Ginecol
Año:
1993
Tipo del documento:
Article