[The protective activity of the adhesion pili of Yersinia pestis]. / Izuchenie protektivnoi aktivnosti pilei adgezii Yersinia pestis.
Zh Mikrobiol Epidemiol Immunobiol
; (5): 26-9, 1995.
Article
en Ru
| MEDLINE
| ID: mdl-8525726
ABSTRACT
Y. pestis adhesion pili (AP) in the native form and in the subunit form, used for immunization in one or two injections in a dose of 12-100 mu g on aluminum hydroxide, did not protect white mice and guinea pigs from experimental Y. pestis infection. The study revealed that AP produced a pronounced cytotoxic effect on macrophages and practically no influence on leukocytes. This result was confirmed in the study of luminol-dependent chemiluminescence and in the analysis of 5'-nucleotidase activity of phagocytes. These data make it possible to regard AP as Y. pestis antimacrophagal pathogenicity factor.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Yersinia pestis
/
Adhesión Bacteriana
/
Fimbrias Bacterianas
Límite:
Animals
Idioma:
Ru
Revista:
Zh Mikrobiol Epidemiol Immunobiol
Año:
1995
Tipo del documento:
Article