The novel monoclonal antibody By114 helps detect the early emergence of a paroxysmal nocturnal hemoglobinuria clone in aplastic anemia.
Exp Hematol
; 23(14): 1484-91, 1995 Dec.
Article
en En
| MEDLINE
| ID: mdl-8542935
ABSTRACT
The newly described monoclonal antibody By114 has been used with flow cytometry to investigate the status of the 90-kD glycosylphosphatidyl-inositol (GPI)-anchored component of CD66 (CD66c) on neutrophils from nine patients with paroxysmal nocturnal hemoglobinuria (PNH), seven with aplastic anemia/PNH, and 63 with aplastic anemia (AA) and a negative Ham's test. We have found that By114 is a sensitive indicator for recognizing patients with PNH and has helped delineate a group of nine patients with aplastic anemia and a negative Ham's test who have evidence of a larger PNH clone than indicated by other monoclonal antibodies (mAbs). By114 is a valuable marker for detecting the emergence of a PNH clone before the Ham's test becomes positive and is a more sensitive detector of deficient GPI-anchored proteins than other mAbs.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Glicosilfosfatidilinositoles
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Hemoglobinuria Paroxística
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Anemia Aplásica
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Anticuerpos Monoclonales
Límite:
Adolescent
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Adult
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Aged
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Child
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Exp Hematol
Año:
1995
Tipo del documento:
Article
País de afiliación:
Reino Unido