Establishment of immortal hepatocytes from a CYP3A7-transgenic/p53-knockout mouse.
Biochem Biophys Res Commun
; 217(3): 1001-5, 1995 Dec 26.
Article
en En
| MEDLINE
| ID: mdl-8554550
Immortal hepatocytes were established from a CYP3A7-transgenic/p53-knockout mouse. The cells could be maintained with shorter doubling time after culture for 1 month. Detectable amounts of CYP3A7 mRNA and the activity of 7-propoxycoumarin O-depropylase, one of the representative CYP3A activities, were present in the immortal hepatocytes. Albumin mRNA, which is specifically expressed in the liver, remained in these cells.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
7-Alcoxicumarina O-Dealquilasa
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Sistema Enzimático del Citocromo P-450
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Hígado
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
1995
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Estados Unidos