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Relationship of timing of agonist administration in the cycle phase to the ovarian response to gonadotropins in the long down-regulation protocols for assisted reproductive technologies.
Ferraretti, A P; Magli, C; Feliciani, E; Montanaro, N; Gianaroli, L.
Afiliación
  • Ferraretti AP; Reproductive Medicine Unit, Società Italiana per gli Studi sulla Medicina della Riproduzione srl, Bologna, Italy.
Fertil Steril ; 65(1): 114-21, 1996 Jan.
Article en En | MEDLINE | ID: mdl-8557125
OBJECTIVE: To assess whether the ovarian response to exogenous gonadotropins and cycle performance is affected by different timing of an agonist administration in long down-regulation protocols. DESIGN: An agonist was administered irrespective of cycle phase, with exogenous gonadotropin beginning 15 days later. PATIENTS: Five hundred fifty-seven normovulatory infertile patients, aged < or = 38 years, were classified into seven study groups, depending on the phase of the cycle in which agonist was started. MAIN OUTCOME MEASURES: Endocrine profile, amount of exogenous stimulation, occurrence of ovarian cysts, mean number of oocytes recovered and embryos transferred, pregnancy rate, implantation rate, and live-birth rate of the seven groups. RESULTS: The ovarian response of the groups did not show any statistically significant differences in relation to the initiation of the agonist. The only effect was a different incidence of ovarian cyst formation, but this phenomenon did not affect cycle performance. The pregnancy, implantation, and live-birth rates showed differences that did not reach statistical significance. CONCLUSION: Agonists initiation can be programmed in advance irrespective of the phase of the cycle. This approach can be of help for the logistics of assisted reproduction programs.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ovario / Fertilización In Vitro / Buserelina / Transferencia de Embrión Tipo de estudio: Etiology_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Fertil Steril Año: 1996 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ovario / Fertilización In Vitro / Buserelina / Transferencia de Embrión Tipo de estudio: Etiology_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Fertil Steril Año: 1996 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos