Mevalonate pathway and isoprenoids regulate human bronchial myocyte proliferation.
Eur J Pharmacol
; 291(2): 201-3, 1995 Oct 15.
Article
en En
| MEDLINE
| ID: mdl-8566171
ABSTRACT
The role of mevalonate and geranylgeraniol in the control of cellular proliferation of cultured human bronchial myocytes was examined by investigating the effect of simvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme in mevalonate synthesis. Simvastatin inhibited the rate of growth of human bronchial smooth muscle cells in a concentration-dependent manner, with an IC50 value of 0.97 +/- 0.1 microM. Mevalonate (100 microM), as well as geranylgeraniol (5 microM), at their highest non-toxic concentrations, restored cell proliferation to control levels.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bronquios
/
Lovastatina
/
Diterpenos
/
Pulmón
/
Ácido Mevalónico
Límite:
Humans
Idioma:
En
Revista:
Eur J Pharmacol
Año:
1995
Tipo del documento:
Article
País de afiliación:
Italia