Vincristine treatment triggering the expression of asymptomatic Charcot-Marie-Tooth disease.
Med Pediatr Oncol
; 26(4): 280-3, 1996 Apr.
Article
en En
| MEDLINE
| ID: mdl-8600343
ABSTRACT
A 16-year-old male suffering from Ewing's sarcoma of the pelvis was treated with vincristine as part of his chemotherapeutic protocol. The boy was never known to suffer from any neurological problems. His father had a mild limp, attributed to prolonged "taxi driving," that was never investigated medically. The first course of treatment, which included 2 mg of vincristine, resulted in clinical improvement. However, at the same time the patient developed severe weakness of both upper and lower limbs, areflexia, and gradually a pes cavus deformity. Nerve conduction studies were suggestive of severe peripheral sensorimotor neuropathy, axonal and demyelinative. A definite diagnosis of Charcot-Marie-Tooth was confirmed by molecular analysis showing the typical duplication of 1.5 megabases at 17 p11.2. This unique manifestation of vincristine neurotoxicity is reported and discussed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hueso Púbico
/
Sarcoma de Ewing
/
Vincristina
/
Neoplasias Óseas
/
Enfermedad de Charcot-Marie-Tooth
/
Isquion
/
Antineoplásicos Fitogénicos
Tipo de estudio:
Guideline
Límite:
Adolescent
/
Humans
/
Male
Idioma:
En
Revista:
Med Pediatr Oncol
Año:
1996
Tipo del documento:
Article
País de afiliación:
Israel