The organelles containing porcine 17 beta-estradiol dehydrogenase are peroxisomes.
Eur J Cell Biol
; 68(3): 263-7, 1995 Nov.
Article
en En
| MEDLINE
| ID: mdl-8603678
ABSTRACT
Porcine 17 beta-estradiol dehydrogenase was recently purified and cloned. It catalyzes the NAD(+)-dependent oxidation of estradiol to estrone 360-fold more efficiently than the reverse reaction with NADPH. Immunogold electron microscopy localizes 17 beta-estradiol dehydrogenase in organelles of 120 to 500 nm with moderate electron-dense matrices bounded by single membranes. Antibodies against the peroxisomal markers catalase and acyl-CoA oxidase recognize the same organelles in double-labeling studies. This is the first report on the participation of peroxisomes in the metabolism of estradiol.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estradiol Deshidrogenasas
/
Microcuerpos
Límite:
Animals
Idioma:
En
Revista:
Eur J Cell Biol
Año:
1995
Tipo del documento:
Article
País de afiliación:
Alemania