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Variation of phylloquinone (vitamin K1) concentrations in hemodialysis patients.
Kohlmeier, M; Saupe, J; Drossel, H J; Shearer, M J.
Afiliación
  • Kohlmeier M; Dept. of Nutrition, School of Medicine, UNC, Chapel Hill 27599-7400, USA.
Thromb Haemost ; 74(5): 1252-4, 1995 Nov.
Article en En | MEDLINE | ID: mdl-8607104
Intra- and interindividual variation of phylloquinone (vitamin K1) concentrations was investigated by repeat analysis of serum from 28 hemodialysis patients with different apolipoprotein E genotypes. Phylloquinone concentrations ranged from 0.1 to 9.0 nM, with a mean of 1.08 nM (standard deviation 1.90 nM). Most of the variation in serum phylloquinone concentrations was due to differences between patients; the ratio of intra- to interindividual variation was 0.17. Serum triglyceride concentrations and apoE genotype together accounted for 64% of interindividual variation; in contrast, only 6% of intraindividual variation could be attributed to differences in triglyceride concentrations. The small residual variance implies that different phylloquinone consumption levels contributed relatively little to the variation of serum concentrations ( < 36% of interindividual variance). The results suggest that individual disposition is a more important determinant of serum phylloquinone concentrations than dietary phylloquinone intake.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina K 1 / Insuficiencia Renal Límite: Aged / Humans / Middle aged Idioma: En Revista: Thromb Haemost Año: 1995 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina K 1 / Insuficiencia Renal Límite: Aged / Humans / Middle aged Idioma: En Revista: Thromb Haemost Año: 1995 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania