Helicobacter pylori augments the pH-increasing effect of omeprazole in patients with duodenal ulcer.
Gastroenterology
; 110(3): 725-32, 1996 Mar.
Article
en En
| MEDLINE
| ID: mdl-8608881
ABSTRACT
BACKGROUND & AIMS:
Omeprazole is less effective in healthy subjects than in patients with duodenal ulcers. The aim of this study was to determine whether Helicobacter pylori augments the pH-increasing effect of omeprazole in patients with duodenal ulcers.METHODS:
In 16 patients with duodenal ulcers, baseline intragastric acidity was measured before and 4-6 weeks after the cure of H. pylori infection. In 17 patients with duodenal ulcers, 24-hour pH metry was performed during treatment with 20 mg omeprazole once daily before as well as after eradication of H. pylori. Intragastric acidity was measured using a glass electrode placed 5 cm below the cardia. H. pylori infection was assessed by [13C] urea breath test, culture, histology, and rapid urease test.RESULTS:
H. pylori eradication resulted in marked decrease of the pH-increasing effect of omeprazole (24-hour median gastric pH, 5.5 vs. 3.0; P<0.002) that was most pronounced during nighttime (median gastric pH, 6.4 vs. 2.1; P=0.001). On the other hand, baseline intragastric pH remained unchanged after eradication (median gastric pH, 1.0 vs. 1.1; P=0.5).CONCLUSIONS:
In patients with duodenal ulcers treated with omeprazole, intragastric pH depends significantly on the presence or absence of H. pylori, whereas baseline pH remained unchanged after H. pylori eradication.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Omeprazol
/
Helicobacter pylori
/
Úlcera Duodenal
/
Ácido Gástrico
/
Antiulcerosos
Tipo de estudio:
Clinical_trials
/
Etiology_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Gastroenterology
Año:
1996
Tipo del documento:
Article
País de afiliación:
Alemania