Occipital cortico-pyramidal projection in hypothyroid rats.
Brain Res Dev Brain Res
; 89(2): 227-34, 1995 Nov 21.
Article
en En
| MEDLINE
| ID: mdl-8612326
ABSTRACT
It is well established that the progressive disappearance of a transient occipito-spinal projection in neonatal rats involves the selective elimination of axonal collaterals. We studied whether the development of the occipito-spinal pathway was affected by hypothyroidism induced by treatment with the goitrogen 6n-propyl-2-thiouracil (PTU) beginning prenatally. Using both anterograde (biocytin and Dil) and retrograde (horseradish peroxidase and Fast Blue) tracing techniques in adult hypothyroid rats, we found that many cells with projections into the pyramidal tract are present in regions of visual cortex that are devoid of such cells in normal adult rats. Our results suggest that hypothyroidism induced by PTU treatment leads to the maintenance of occipito-spinal projections that are normally transient.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tractos Piramidales
/
Corteza Visual
/
Hipotiroidismo
/
Lóbulo Occipital
Límite:
Animals
Idioma:
En
Revista:
Brain Res Dev Brain Res
Asunto de la revista:
CEREBRO
/
NEUROLOGIA
Año:
1995
Tipo del documento:
Article
País de afiliación:
Estados Unidos