The diurnal variation of hepatic HMG-CoA reductase activity is due to changes in the level of immunoreactive protein.
Arch Biochem Biophys
; 327(1): 41-4, 1996 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-8615694
ABSTRACT
The diurnal variation in levels of hepatic HMG-CoA reductase immunoreactive protein and enzyme activity were determined in rats. Immunoreactive protein levels changed together with enzyme activity. Thus the catalytic efficiency of HMG-CoA reductase was not significantly changed. The data suggest that the diurnal variation in hepatic HMG-CoA reductase activity is due to changes in enzyme protein levels rather than changes in phosphorylation state of the enzyme, for example, which would cause changes in catalytic efficiency.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Microsomas Hepáticos
/
Ritmo Circadiano
/
Hidroximetilglutaril-CoA Reductasas
Límite:
Animals
Idioma:
En
Revista:
Arch Biochem Biophys
Año:
1996
Tipo del documento:
Article
País de afiliación:
Estados Unidos