Effect of IL-6 on alveolar fibroblast proliferation in interstitial lung diseases.
Clin Immunol Immunopathol
; 79(3): 244-51, 1996 Jun.
Article
en En
| MEDLINE
| ID: mdl-8635282
ABSTRACT
Alveolar macrophage-fibroblast interaction may be involved in the pathogenesis of interstitial lung diseases (ILD). Herein, we compared IL-6 secretion from alveolar macrophages (AM) and alveolar fibroblasts (AFb) recovered from patients with sarcoidosis (SA) and with diffuse interstitial fibrosis (DIF). Moreover, we evaluated the effect of IL-6 on the in vitro AFb proliferation in both diseases. AM and AFb from SA patients showed increased spontaneous secretion of IL-6 compared with cells from DIF subjects. Tumor necrosis factor-alpha (TNFalpha) and interleukin-1 (IL-1) enhanced IL-6 secretion and IL-6 mRNA transcription in AFb of SA patients. Addition of anti-IL-6 MoAbs increased AFb proliferation capacity in SA, but suppressed it in DIF. These results show that only SA AM and AFb secrete high levels of IL-6 which have suppressive effect on AFb proliferation. This may indicate a potential role of IL-6 in the fibrogenesis of ILD.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Alveolos Pulmonares
/
Interleucina-6
/
Enfermedades Pulmonares Intersticiales
Límite:
Humans
Idioma:
En
Revista:
Clin Immunol Immunopathol
Año:
1996
Tipo del documento:
Article
País de afiliación:
Israel