Absorption of different amino acids by an intestinal preparation from normal rats and from rats exposed to supralethal X-irradiation.
Radiat Environ Biophys
; 14(1): 53-60, 1977 Apr 27.
Article
en En
| MEDLINE
| ID: mdl-866585
ABSTRACT
Absorption of different amino acids [lysine, alpha-amino isobutyrate (AIB), methionine, alanine, glycine] was studied in an intestinal in vivo preparation from normal and X-irradiated rats (1 and 3 days after 2000 R). Absorption of amino acids under loading and in presence of other amino acids was also followed. Lysine and AIB absorption follow a saturation kinetics with a maximal velocity of 35 and 85.6 micronmoles/min and a Kt of 10 and 67 micronmoles for lysine and AIB respectively. Interference in absorption exists not only between amino acids of the same class, but also by lysine on neutral amino acids. One day after irradiation, absorption is normal or even enhanced, although active transport appears impaired as indicated by the increase in Kt. Three days after exposure absorption, particularly the active one, is severely depressed. This is indicated by the low Vm and high Kt as well as by the fact that loading has little influence on absorption.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Traumatismos Experimentales por Radiación
/
Aminoácidos
/
Absorción Intestinal
Límite:
Animals
Idioma:
En
Revista:
Radiat Environ Biophys
Año:
1977
Tipo del documento:
Article