Early defect of immunoregulatory T cells in autoimmune diabetes.
C R Acad Sci III
; 319(2): 125-9, 1996 Feb.
Article
en En
| MEDLINE
| ID: mdl-8680958
ABSTRACT
A potential immunoregulatory function has recently been attributed to the discrete subset of major histocompatibility complex (MHC) class I-restricted TCR-alpha beta mature thymocytes expressing an unusual V beta 8-biased T cell receptor repertoire. This T cell subset which also selectively express the CD44 marker is the main IL-4 producer in the thymus. Nonobese diabetic (NOD) mice were found to have a marked deficit in the number and functional capacity of CD44+ TCR-alpha beta+ thymocytes from as early as 3 weeks of age. The deficiency in IL-4 production was completely corrected after incubation with interleukin-7 (IL-7), a selective growth factor for CD44+ TCR-alpha beta+ mature thymocytes. This abnormality in T cell differentiation could explain the Th2 functional deficiency that may be a key element in the emergence of Th1-driven autoimmune disease in NOD mice.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Subgrupos de Linfocitos T
/
Diabetes Mellitus Tipo 1
Límite:
Animals
Idioma:
En
Revista:
C R Acad Sci III
Asunto de la revista:
BIOLOGIA
Año:
1996
Tipo del documento:
Article
País de afiliación:
Francia