Calf's lung surfactant extract in acute hypoxemic respiratory failure in children.
Crit Care Med
; 24(8): 1316-22, 1996 Aug.
Article
en En
| MEDLINE
| ID: mdl-8706485
ABSTRACT
OBJECTIVE:
Open-label trial of the safety and short-term efficacy of calf's lung surfactant in pediatric respiratory failure.DESIGN:
Multi-institutional, uncontrolled, observational trial.SETTING:
Six pediatric intensive care units of tertiary medical centers. PATIENTS Twenty-nine children with acute hypoxemic respiratory failure, characterized by diffuse, bilateral, pulmonary infiltrates, need for ventilator support, and an oxygenation index of > or = 7.INTERVENTIONS:
Up to four doses of intratracheal surfactant (80 mL/m2). MEASUREMENTS AND MAINRESULTS:
Ventilator parameters, arterial blood gases, and derived oxygenation and ventilation indices were recorded before, and at intervals after, surfactant administration. Complications and outcome measures were also noted. There was immediate improvement in oxygenation and moderation of ventilator support associated with surfactant administration in 24 of 29 patients. A modest but statistically insignificant effect was seen with subsequent doses. The only complications occurred in three patients who developed airleaks, two of which were coincident with surfactant administration. The overall mortality rate was 14%, which compares favorably with other published series.CONCLUSIONS:
Administration of calf's lung surfactant appears to be safe and is associated with rapid improvement in oxygenation and moderation of ventilator support in children with acute hypoxemic respiratory failure. These results set the stage for a randomized, controlled study.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Síndrome de Dificultad Respiratoria
/
Insuficiencia Respiratoria
/
Surfactantes Pulmonares
Tipo de estudio:
Clinical_trials
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Observational_studies
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Risk_factors_studies
Límite:
Adolescent
/
Animals
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Revista:
Crit Care Med
Año:
1996
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
EEUU
/
ESTADOS UNIDOS
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ESTADOS UNIDOS DA AMERICA
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EUA
/
UNITED STATES
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UNITED STATES OF AMERICA
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US
/
USA