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Thrombotic vascular risk factors in inflammatory bowel disease.
Hudson, M; Chitolie, A; Hutton, R A; Smith, M S; Pounder, R E; Wakefield, A J.
Afiliación
  • Hudson M; University Department of Medicine, Royal Free Hospital School of Medicine, London.
Gut ; 38(5): 733-7, 1996 May.
Article en En | MEDLINE | ID: mdl-8707120
BACKGROUND: Thrombosis may be an important effector mechanism in the pathogenesis of Crohn's disease. METHODS: This study therefore investigated the prevalence of independent thrombotic risk factors (factor VII coagulant activity, lipoprotein (a), fibrinogen, plasma triglycerides, and smoking) in patients with Crohn's disease, ulcerative colitis, and normal controls. RESULTS: In Crohn's disease (n = 75), the mean plasma VII:C, lipoprotein (a) and fibrinogen concentrations were significantly greater than in the normal population (n = 85). In ulcerative colitis (n = 35), only the mean factor VII:C concentration was significantly higher than normal. Ninety three per cent of patients with Crohn's disease and 86% of those with ulcerative colitis had at least one risk factor for thrombotic vascular disease, compared with 61% of the normal population (p < 0.001). CONCLUSIONS: In many young patients with inflammatory bowel disease, plasma concentrations of these prothrombotic factors were in excess of the limits that are regarded as posing an increased risk for the development of occlusive vascular disease.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombosis / Factor VII / Fibrinógeno / Colitis Ulcerosa / Enfermedad de Crohn / Lipoproteína(a) Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Gut Año: 1996 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombosis / Factor VII / Fibrinógeno / Colitis Ulcerosa / Enfermedad de Crohn / Lipoproteína(a) Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Gut Año: 1996 Tipo del documento: Article Pais de publicación: Reino Unido