Ret and trk proto-oncogene activation in thyroid papillary carcinomas in French patients from the Champagne-Ardenne region.
Clin Biochem
; 29(3): 267-71, 1996 Jun.
Article
en En
| MEDLINE
| ID: mdl-8740514
ABSTRACT
OBJECTIVES:
To investigate the presence of ret and trk proto-oncogene rearrangements in thyroid tumors. DESIGN ANDMETHODS:
High-molecular-weight DNA was extracted from 36 thyroid tumors (1 multinodular goiter, 14 follicular adenomas, 16 papillary carcinomas, 1 lymph node metastasis of a papillary carcinoma, 1 follicular carcinoma, and 3 medullary carcinomas) and 22 adjacent tissues. Southern blot analysis was performed after digestion with EcoR1 or BamH1, using specific probes for ret and trk.RESULTS:
Only 2 ret rearrangements were found in 2 papillary carcinomas (overall frequency 6%; papillary carcinoma frequency 13%). All normal or tumor samples were negative for the presence of a trk rearrangement.CONCLUSIONS:
The previous data from the literature are highly conflicting, ranging from 0 to 30% of activation. Our results could be, therefore, classified as medium between these extreme values. It seems, therefore, that genetic and/or geographical factors could play a role in ret and trk proto-oncogene activation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Tiroides
/
Carcinoma Papilar
/
Proteínas Proto-Oncogénicas
/
Receptores de Factor de Crecimiento Nervioso
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Proteínas Tirosina Quinasas Receptoras
/
Proteínas de Drosophila
Límite:
Adult
/
Aged
/
Female
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Humans
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Male
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Clin Biochem
Año:
1996
Tipo del documento:
Article
País de afiliación:
Francia