Synthesis and receptor binding affinity of cholecystokinin receptor ligands: 2-and 1-indolyl derivatives of PD134308.
Farmaco
; 51(7): 471-6, 1996 Jul.
Article
en En
| MEDLINE
| ID: mdl-8765669
ABSTRACT
The synthesis of two "dipeptoids" structurally related to the CCK-B antagonist CI-988 (PD134308) is described. The 2- and 1-indolyl derivatives 4a, b were prepared in order to define the role of the tryptophan moiety in this series of "dipeptoids". They were evaluated as competitors in the binding of [3H]-CCK8S on guinea pig brain CCK-B receptors.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores de Colecistoquinina
/
Antagonistas de Hormonas
/
Indoles
/
Meglumina
Límite:
Animals
Idioma:
En
Revista:
Farmaco
Asunto de la revista:
FARMACOLOGIA
/
QUIMICA
Año:
1996
Tipo del documento:
Article
País de afiliación:
Italia