A systemic and cellular model for zidovudine plasma concentrations and intracellular phosphorylation in patients.
J Infect Dis
; 174(3): 490-9, 1996 Sep.
Article
en En
| MEDLINE
| ID: mdl-8769605
ABSTRACT
In a pharmacokinetic model for the systemic and cellular disposition of zidovudine in patients, serial measurements of plasma zidovudine and intracellular metabolites were used to simultaneously characterize systemic pharmacokinetics and intracellular phosphorylation in 6 human immunodeficiency virus-infected patients. First-order processes are sufficient to describe zidovudine monophosphate kinetics in peripheral blood mononuclear cells (PBMC), and the pharmacokinetic model provided reliable parameter estimates for each subject. The amount of zidovudine monophosphate in PBMC was inversely correlated with plasma zidovudine concentrations, and patients with higher systemic clearance had less intracellular zidovudine monophosphate. Zidovudine triphosphate values were measurable but not different at each time point. Lower lymphocyte counts were associated with higher intracellular zidovudine monophosphate but lower zidovudine triphosphate. The pharmacokinetic model proposed provides a quantitative link between systemic zidovudine concentrations and zidovudine monophosphate in PBMC from patients that will be useful in evaluating alternative therapeutic strategies.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Zidovudina
/
Infecciones por VIH
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Infect Dis
Año:
1996
Tipo del documento:
Article
País de afiliación:
Estados Unidos