T cell receptor (TCR) repertoire in alloimmune responses.
Int Rev Immunol
; 13(3): 187-207, 1996.
Article
en En
| MEDLINE
| ID: mdl-8782741
ABSTRACT
A large number of alloantigenic determinants could be generated by both the direct and indirect alloantigen presentation pathways. Hence, a heterogeneous population of T cells expressing a wide variety of receptors would be expected to respond to this diverse array of alloantigenic determinants. However, T cells expressing highly restricted T cell receptor (TCR) variable genes have been reported in a variety of alloimmune responses. A similar phenomenon has been observed in a wide variety of other immune responses, from those induced by superantigens, to very specific responses induced by a single peptide presented by a single MHC molecule. Given this scenario, the limited number of T cell clones which dominate an allograft rejection response, or for that matter an autoimmune response or a tumor specific response, could be therapeutically targeted by virtue of the selected TCR expression.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores de Antígenos de Linfocitos T
/
Linfocitos T
/
Presentación de Antígeno
/
Isoantígenos
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Int Rev Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
1996
Tipo del documento:
Article
País de afiliación:
Estados Unidos