Serotonin metabolite excretion after postmenopausal estradiol therapy.
Maturitas
; 24(1-2): 37-41, 1996 May.
Article
en En
| MEDLINE
| ID: mdl-8794432
ABSTRACT
Serotonin, known for its beneficial action on mood and well-being, is also involved in cardiovascular functions. Thus the current work was undertaken to study the effect of hormone replacement therapy on serotonin turnover in postmenopausal women. Eighteen women received estradiol transdermally and 17 women estradiol valerate orally for 4 weeks. The serotonin metabolite 5-hydroxyindole acetic acid (5-HIAA) was determined in the urine before, and after 2 and 4 weeks' estradiol treatment. With both administration routes estradiol produced a significant increase in urinary 5-HIAA excretion, greatest with transdermal estradiol after 28 days of treatment. The enhancement of serotonin turnover may contribute not only to an improvement of mood and well-being but also to a cardioprotective effect of estradiol observed after hormone substitution in postmenopausal women.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Serotonina
/
Terapia de Reemplazo de Estrógeno
/
Posmenopausia
/
Estradiol
/
Ácido Hidroxiindolacético
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Maturitas
Año:
1996
Tipo del documento:
Article
País de afiliación:
Reino Unido