The ontogeny of the peptide innervation of the human pylorus, with special reference to understanding the aetiology and pathogenesis of infantile hypertrophic pyloric stenosis.
J Pediatr Surg
; 31(4): 490-7, 1996 Apr.
Article
en En
| MEDLINE
| ID: mdl-8801298
ABSTRACT
Pyloric stenosis (PS) is a common condition in infancy, which is associated with smooth muscle hypertrophy that results in pyloric outlet obstruction. The author examines the ontogeny of the peptide innervation of the pylorus in fetal tissues and an experimental model in mice and evaluates the histochemical and morphological changes in the pylorus. The data suggest that PS is an intrauterine lesion that occurs by 12 weeks' gestation. This is associated with diminished nitric oxide in human tissues and reduced enzyme activity (resulting from a deficiency in an enzyme cofactor) in mice. Increased vasoactive intestinal polypeptide expression in pyloric myenteric ganglia may be an intrinsic mechanism for resolving this condition.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estenosis Pilórica
/
Péptido Intestinal Vasoactivo
/
Óxido Nítrico Sintasa
/
Plexo Mientérico
/
Óxido Nítrico
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Female
/
Humans
/
Infant
/
Male
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
J Pediatr Surg
Año:
1996
Tipo del documento:
Article
País de afiliación:
Reino Unido