The design and synthesis of substituted biphenyl libraries.
Bioorg Med Chem
; 4(5): 659-66, 1996 May.
Article
en En
| MEDLINE
| ID: mdl-8804530
ABSTRACT
A novel scaffold system for the generation of diversity libraries has been designed which allows for rapid modification not only of functional groups, but their spatial arrangements as well. The biphenyl scaffold allows for display of three or four diverse functional groups in a wide variety of spatial arrangements depending on the substitution pattern selected. The libraries are generated by a combination of solution and solid-phase chemistries and are cleaved off the solid-support for screening.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Compuestos de Bifenilo
/
Diseño de Fármacos
Idioma:
En
Revista:
Bioorg Med Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
1996
Tipo del documento:
Article
País de afiliación:
Estados Unidos