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Fos oncoprotein expression in the rat forebrain following muscimol-induced absence seizures.
Zhang, X; Le Gal La Salle, G; Ridoux, V; Yu, P H; Ju, G.
Afiliación
  • Zhang X; Department of Neurobiology, Institute of Neurosciences, Xian, People's Republic of China.
Neurosci Lett ; 210(3): 169-72, 1996 Jun 07.
Article en En | MEDLINE | ID: mdl-8805122
ABSTRACT
Fos oncoprotein expression is a marker of neuronal activation following seizures. Here, using this method we examined the anatomical locations of muscimol-induced absence seizures in the rat forebrain. Six hours after a systemic injection of muscimol a massive Fos immunoreactivity appeared in the olfactory system, retrosplenial cortex and paraventricular thalamic nucleus, whereas other cortical areas contained low level of Fos expression. These results provide the first functional morphological evidence suggesting that these forebrain structures with Fos expression may play an important role in the pathophysiology of muscimol-induced absence seizures.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Convulsiones / Proteínas Proto-Oncogénicas c-fos / Prosencéfalo / Epilepsia Tipo Ausencia / Agonistas del GABA / Muscimol Límite: Animals Idioma: En Revista: Neurosci Lett Año: 1996 Tipo del documento: Article
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Convulsiones / Proteínas Proto-Oncogénicas c-fos / Prosencéfalo / Epilepsia Tipo Ausencia / Agonistas del GABA / Muscimol Límite: Animals Idioma: En Revista: Neurosci Lett Año: 1996 Tipo del documento: Article