Fos oncoprotein expression in the rat forebrain following muscimol-induced absence seizures.
Neurosci Lett
; 210(3): 169-72, 1996 Jun 07.
Article
en En
| MEDLINE
| ID: mdl-8805122
ABSTRACT
Fos oncoprotein expression is a marker of neuronal activation following seizures. Here, using this method we examined the anatomical locations of muscimol-induced absence seizures in the rat forebrain. Six hours after a systemic injection of muscimol a massive Fos immunoreactivity appeared in the olfactory system, retrosplenial cortex and paraventricular thalamic nucleus, whereas other cortical areas contained low level of Fos expression. These results provide the first functional morphological evidence suggesting that these forebrain structures with Fos expression may play an important role in the pathophysiology of muscimol-induced absence seizures.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Convulsiones
/
Proteínas Proto-Oncogénicas c-fos
/
Prosencéfalo
/
Epilepsia Tipo Ausencia
/
Agonistas del GABA
/
Muscimol
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
1996
Tipo del documento:
Article