Probucol reduces hepatic cholesterol secretion in hyperlipidemic Yoshida rats.
Atherosclerosis
; 119(2): 223-33, 1996 Jan 26.
Article
en En
| MEDLINE
| ID: mdl-8808499
ABSTRACT
In this study, perfused livers from Yoshida rats, either on a normal diet or on a diet with 0.3% probucol, were examined. The analysis of liver lipid content and of bile and lipoprotein secretion changes showed that probucol had a relevant effect on liver lipid biosynthesis. In particular, it reduced the production of triacylglycerols and, to a much greater extent that of cholesterol. In addition, probucol reduced plasma cholesterol concentration by decreasing esterified cholesterol in HDL1 and HDL2 fractions. Furthermore, HDL1 composition of both hepatic neosynthetized and circulating particles was strongly modified by probucol. Finally, probucol did not appear to induce significant differences in lipid bile secretion while phospholipid secretion from perfused livers was increased. These facts suggest that the hypolipidemic action of probucol is not mediated by an increase in bile steroid secretion, but rather by a direct reduction in hepatic lipoprotein cholesterol secretion. This secretion induces a modified plasma profile of HDL particles such that these variations are advantageous in terms of reverse cholesterol transport.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Probucol
/
Colesterol
/
Hiperlipidemias
/
Hígado
/
Anticolesterolemiantes
Límite:
Animals
Idioma:
En
Revista:
Atherosclerosis
Año:
1996
Tipo del documento:
Article
País de afiliación:
Italia