Effect of carnitine on decrease of branched chain amino acids and glutamine in serum of septic rats.
Biol Pharm Bull
; 19(1): 157-9, 1996 Jan.
Article
en En
| MEDLINE
| ID: mdl-8820932
ABSTRACT
Blood concentrations of branched chain amino acids (BCAA; leucine, isoleucine, and valine) and glutamine (Gln) decrease markedly in sepsis. We investigated the effect of carnitine on serum concentrations of BCAA and Gln in fasted septic rats. Rats were made septic by cecal ligation and puncture. They developed extremely high blood concentrations of endotoxin, and serum concentrations of BCAA and Gln were markedly decreased 2 d after the operation. When L-carnitine was administered subcutaneously to the rats at 500 mg/kg body weight every 12 h for 2 d starting at the operation, no decrease in the serum concentrations of BCAA and Gln was observed. This indicates that the administration of carnitine can prevent the decrease of serum concentrations of BCAA and Gln in septic animals.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carnitina
/
Sepsis
/
Aminoácidos de Cadena Ramificada
/
Glutamina
Límite:
Animals
Idioma:
En
Revista:
Biol Pharm Bull
Asunto de la revista:
BIOQUIMICA
/
FARMACOLOGIA
Año:
1996
Tipo del documento:
Article
País de afiliación:
Japón