Psychosocial consequences of DNA analysis for MEN type 2.
Oncology (Williston Park)
; 10(2): 141-6; discussion 146, 152, 157, 1996 Feb.
Article
en En
| MEDLINE
| ID: mdl-8838257
ABSTRACT
Multiple endocrine neoplasia type 2 (MEN-2) is characterized by medullary thyroid carcinoma in combination with pheochromocytomas and, sometimes, parathyroid adenomas. Since 1993, the psychosocial implications of DNA analysis for MEN-2 have been studied in the Netherlands. This article summarizes the first results of that study. Individuals who applied for DNA analysis cited the need to reduce uncertainty as the major reason for wanting the test. An unfavorable test outcome resulted in anxiety and depression but also relief. Immediate preventive treatment was preferred to continued periodic screening. Carriers were preoccupied with disease-related complaints, and identified with other carriers and MEN-2 patients. A favorable test led, in most applicants and partners, to both relief and worry. Some noncarriers felt guilty and isolated from their families. One year after counseling, participants reported fewer psychosomatic complaints.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ADN de Neoplasias
/
Neoplasia Endocrina Múltiple Tipo 2a
/
Asesoramiento Genético
Tipo de estudio:
Etiology_studies
Límite:
Adolescent
/
Adult
/
Humans
Idioma:
En
Revista:
Oncology (Williston Park)
Asunto de la revista:
NEOPLASIAS
Año:
1996
Tipo del documento:
Article
País de afiliación:
Países Bajos