Embryotoxicity and teratogenicity studies of poly (DL-lactide-co-glycolide) microspheres incorporated tetanus toxoid in Wistar rats.
Hum Exp Toxicol
; 15(4): 349-51, 1996 Apr.
Article
en En
| MEDLINE
| ID: mdl-8845225
ABSTRACT
Tetanus Toxoid loaded biodegradable microspheres (MTT) (poly (DL-Lactide-co-Glycolide) were administered intramuscularly to pregnant Wistar rats from Days 6 to 15 of gestation, at 1, 5 and 10-times the human equivalent dose of TT. Developmental defects in relation to soft tissues and skeleton, weight and sex of live pups and early fetal deaths from treated and control rats were analysed. The findings in treatment groups were comparable to those in the controls. These observations show that MTT was safe for pregnant rats and developing pups.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácido Poliglicólico
/
Polímeros
/
Teratógenos
/
Toxoide Tetánico
/
Ácido Láctico
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Hum Exp Toxicol
Asunto de la revista:
TOXICOLOGIA
Año:
1996
Tipo del documento:
Article
País de afiliación:
India