Ranitidine therapy for esophagitis in children with developmental disabilities.
Clin Pediatr (Phila)
; 35(9): 451-6, 1996 Sep.
Article
en En
| MEDLINE
| ID: mdl-8877242
ABSTRACT
Esophagitis is common in children with cerebral palsy. Because histamine2-receptor antagonists such as ranitidine have not been uniformly effective, we treated disabled children with esophagitis with greater than usual doses. Endoscopy and pH monitoring were used to monitor dose and response to treatment. A dose of 9.3 +/- 0.9 mg/kg/day did not improve visual or microscopic esophagitis after 3 months. A dose of 14.8 +/- 3.9 mg/kg/day resulted in only slight microscopic improvement, but symptoms were improved. There was no correlation between esophageal reflux index at enrollment and either severity of esophagitis or response to treatment. Elevation of gastric pH by ranitidine was infrequent. These results affirm that pH monitoring does not reliably identify disabled children with reflux esophagitis nor does ranitidine reliably heal this disorder.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ranitidina
/
Discapacidades del Desarrollo
/
Esofagitis
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Clin Pediatr (Phila)
Año:
1996
Tipo del documento:
Article
País de afiliación:
Estados Unidos