Degradation kinetics and isomerization of cefdinir, a new oral cephalosporin, in aqueous solution. 1.
J Pharm Sci
; 85(9): 976-83, 1996 Sep.
Article
en En
| MEDLINE
| ID: mdl-8877890
Hydrolytic degradation products of cefdinir were studied in acidic (pH 1), neutral (pH 6), and basic (pH 9) solutions. Seven major degradation products were isolated by preparative and/or high-performance liquid chromatography and characterized by UV, IR, 1H-NMR, and mass spectra. To clarify degradation pathways in each pH solution, kinetic and product analyses during hydrolysis of cefdinir were carried out along with the followup reaction of representative degradation products. Cefdinir was shown to degrade via two major degradation routes: beta-lactam ring-opening and pH-dependent isomerizations (lactonization, epimerization at C-6 or C-7, syn-anti isomerization of N-oxime function).
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cefalosporinas
Idioma:
En
Revista:
J Pharm Sci
Año:
1996
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Estados Unidos