Inhibition of hepatitis B surface antigen secretion on human hepatoma cells. Components from Rubia cordifolia.
J Nat Prod
; 59(3): 330-3, 1996 Mar.
Article
en En
| MEDLINE
| ID: mdl-8882438
The antiviral activity in the roots of Rubia cordifolia was examined, and three naphthohydroquinones, furomollugin (1), mollugin (2), and rubilactone (3), were isolated from it. Compounds 1 and 2 strongly suppressed the secretion of hepatitis B surface antigen (HBsAg), both with IC50 = 2.0 micrograms/mL, in human hepatoma Hep3B cells while having little effect on the viability of the cells. Evaluation of structurally related derivatives of 1 and 2 revealed that a 6-hydroxy group and a pyran or furan ring contribute to this suppressive effect.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Piranos
/
Pironas
/
Medicamentos Herbarios Chinos
/
Antígenos de Superficie de la Hepatitis B
/
Neoplasias Hepáticas Experimentales
/
Naftoles
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Nat Prod
Año:
1996
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Estados Unidos