Role of atheroma liposomes and malondialdehyde-modified low-density lipoproteins in complement activation.
Pathobiology
; 64(2): 73-8, 1996.
Article
en En
| MEDLINE
| ID: mdl-8888272
ABSTRACT
We investigated the ability of atheroma-associated liposomes and malondialdehyde (MDA)-modified low-density lipoproteins (MDA-LDL) to activate complement. Complement activation markers C3a, Bb, C4d and SC5b-9 were measured in both normal and complement-deficient sera. We found that MDA-LDL was able to generate C3a and SC5b-9, predominantly by the alternative pathway. High-density lipoproteins modified with MDA were also capable of C3a generation although to a lesser degree. The presence of atheroma-associated liposomes did not result in detectable levels of complement activation markers. We conclude that MDA-modified lipoproteins may represent a possible source for complement activation within atherosclerotic lesions.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Arteriosclerosis
/
Complemento C4b
/
Colesterol
/
Ésteres del Colesterol
/
Activación de Complemento
/
Lipoproteínas LDL
/
Liposomas
/
Malondialdehído
Límite:
Humans
Idioma:
En
Revista:
Pathobiology
Asunto de la revista:
PATOLOGIA
Año:
1996
Tipo del documento:
Article
País de afiliación:
Estados Unidos