Decreased cerebrospinal fluid levels of substance P in Machado-Joseph disease.
J Neurol Sci
; 142(1-2): 107-10, 1996 Oct.
Article
en En
| MEDLINE
| ID: mdl-8902728
ABSTRACT
To clarify the mechanism of brain impairment in Machado-Joseph disease (MJD), we measured the cerebrospinal fluid (CSF) levels of substance P in 7 patients (mean age 45.7 +/- 12.09 years) with this disease. Four patients had type I and three had type II disease. Findings were compared with those obtained in 14 age-matched controls, 8 patients with Parkinson's disease, 7 patients with multiple system atrophy, and 6 patients with myopathy. The CSF level of substance P was significantly (p = 0.0000) lower in the patients with MJD, being 44.5% of the control value. However, the mean CSF levels of substance P in the patients with Parkinson's disease, multiple system atrophy, or myopathy did not differ significantly from that in the control subjects. The alteration in the CSF level of substance P may be related to the neurological impairment observed in MJD.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sustancia P
/
Enfermedad de Machado-Joseph
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Neurol Sci
Año:
1996
Tipo del documento:
Article
País de afiliación:
Japón