Cytokines, growth factors, and other inflammatory mediators in glomerulonephritis.

ABSTRACT

Over the past decade, research has been centered on the identification of factors that mediate glomerular immune injury and the assessment of their roles in this disease process. The spectrum of mediators identified to date encompasses a diverse array of bioactive molecules such as phospholipids, including cytokines and growth factors, and lipid-derived mediators such as eicosanoids. Given the extensive number of potentially important mediators in glomerulonephritis (GN), I focus only on some of them, for which strong in vitro and in vivo data suggest a major role in the pathogenesis of immune-mediated renal injury. So, in the first part, I discuss some cytokines and growth factors; and in the second, some other important mediators, the eicosanoids and especially the lipoxygenase-derived products, leukotrienes and lipoxins.