Measles virus in otosclerosis and the specific immune response of the inner ear.
Acta Otolaryngol
; 116(5): 705-9, 1996 Sep.
Article
en En
| MEDLINE
| ID: mdl-8908246
ABSTRACT
Histologic and immunohistochemical studies of otosclerotic lesions have shown that there is a chronic inflammatory reaction of the otic capsule with bone resorption resulting from vascular invasion accompanied by inflammatory cells. During the active lytic stage of otosclerosis, paramyxoviral structures have been identified by electron microscopy and measles virus antigen expression by immunohistochemistry. Recently, measles virus related sequences have been detected in tissue of otosclerotic lesions. Because the otosclerotic focus has a close relation to the perilymphatic space, the expression of measles virus antigens within it should represent an immunologic challenge to the immune system of the endolymphatic sac. In this study, measles virus specific antibodies were detected in all of the perilymph samples from 19 patients suffering from otosclerosis, and the relative amount of these IgG antibodies was much higher than in serum samples of the same patients or in perilymph of control patients. These findings support the hypothesis that measles viruses play an crucial role in the pathogenesis of otosclerosis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Otosclerosis
/
Oído Interno
/
Virus del Sarampión
/
Anticuerpos Antivirales
/
Antígenos Virales
Tipo de estudio:
Prognostic_studies
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Acta Otolaryngol
Año:
1996
Tipo del documento:
Article
País de afiliación:
Alemania