Cross-species transplantation of photoreceptors with tacrolimus hydrate (FK506) treatment.
Jpn J Ophthalmol
; 39(4): 334-9, 1995.
Article
en En
| MEDLINE
| ID: mdl-8926639
ABSTRACT
Photoreceptors from normal neonatal or transgenic neonatal mice with normally developing retinas were transplanted into the subretinal spaces of normal rats. The animals with transplants received either immunosuppressive treatment with tacrolimus hydrate for the first two weeks after transplantation or no treatment. At 4 weeks after transplantation, graft survival occurred only in rats treated with tacrolimus. In 7 of the 12 treated eyes, photoreceptors survived at least 4 weeks after transplantation. Relatively mature outer segments were found only in 2 eyes in which the retinal grafts formed rosettes.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células Fotorreceptoras
/
Trasplante Heterólogo
/
Tacrolimus
/
Inmunosupresores
Límite:
Animals
Idioma:
En
Revista:
Jpn J Ophthalmol
Año:
1995
Tipo del documento:
Article
País de afiliación:
Japón