New compounds: total synthesis of dl-3a,4,6a-cis-4-(4-carboxybutyl)-hexahydropyrrolo[3,4-d]imidazol-2-one hydrochloride (dl-azabiotin hydrochloride).

ABSTRACT

The total synthesis of dl-3a,4,6a-cis-4(4-carboxybutyl)-hexahydropyrrolol[3,4-d]imidazol-2-one hydrochloride (dl-azabiotin hydrochloride) was accomplished in a seven-step sequence from 2-ethoxycarbonylazepin-7-one.