[Successful treatment of acute non-lymphoblastic leukemia from myelodysplastic syndrome by combination of human macrophage colony-stimulating factor (M-CSF) and low dose cytosine arabinoside: M-CSF-induced proliferation and tyrosine phosphorylation in leukemic blasts].
Rinsho Ketsueki
; 37(11): 1259-64, 1996 Nov.
Article
en Ja
| MEDLINE
| ID: mdl-8960658
ABSTRACT
An 84-year-old woman was admitted with acute non-lymphoblastic leukemia transformed from myelodysplastic syndrome. We examined the signal transduction of the leukemic blasts. Stimulation of the blasts by macrophage colony-stimulating factor (M-CSF) resulted in tyrosine phosphorylation of several cellular proteins. In vitro proliferation of leukemic blasts was stimulated by M-CSF, but not by granulocyte colony-stimulating factor. Based upon these findings, combined therapy with M-CSF and low dose cytosine arabinoside (ara-C) was successful. After her recovery, we confirmed marked reduction of blasts and disappearance of M-CSF-responsive cells. These results suggest that M-CSF could enhance the cytotoxic effect of ara-C on leukemic blasts via its intracellular signaling pathway linked to proliferation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tirosina
/
Síndromes Mielodisplásicos
/
Leucemia Mieloide Aguda
/
Crisis Blástica
/
Factor Estimulante de Colonias de Macrófagos
/
Citarabina
/
Antimetabolitos Antineoplásicos
Límite:
Aged
/
Aged80
/
Female
/
Humans
Idioma:
Ja
Revista:
Rinsho Ketsueki
Año:
1996
Tipo del documento:
Article