The potential biological and clinical significance of the soluble tumor necrosis factor receptors.
Cytokine Growth Factor Rev
; 7(3): 231-40, 1996 Oct.
Article
en En
| MEDLINE
| ID: mdl-8971478
ABSTRACT
The role of TNF receptors (TNF-Rs) is not limited to signal transduction but includes extracellular regulatory functions affecting systemic TNF bioavailability. This review summarizes the regulation of TNF-R shedding and its kinetics, the complex interaction between the soluble receptors and their ligand in vitro and in vivo, and the potential diagnostic, prognostic and therapeutic value of the soluble receptors in malignant, inflammatory, infectious and autoimmune disorders.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Autoinmunes
/
Receptores del Factor de Necrosis Tumoral
/
Sepsis
/
Inflamación
/
Neoplasias
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cytokine Growth Factor Rev
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
BIOQUIMICA
Año:
1996
Tipo del documento:
Article
País de afiliación:
Israel