Single or multiple dose ursodeoxycholic acid for cholestatic liver disease: biliary enrichment and biochemical response.
J Hepatol
; 25(6): 887-94, 1996 Dec.
Article
en En
| MEDLINE
| ID: mdl-9007717
ABSTRACT
BACKGROUND:
Ursodeoxycholic acid (UDCA) improves liver biochemistry in primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). Since UDCA acts partly by reducing the intestinal absorption of hydrophobic endogenous bile salts and is poorly absorbed from the intestine, a multiple dose regimen has been advocated. Single dose treatment, on the other hand, may improve compliance.AIM:
The effects of a single or multiple dose regimen on liver enzymes and serum and biliary bile salts composition were evaluated.METHODS:
Twenty-seven patients (19 PSC, 8 PBC), most with early stage disease, received UDCA (10 mg kg-1 day-1) in a single dose at bed time (n = 13) or in three divided gifts with meals (n = 14) over 3 months. Five patients had both treatment regimens in random order with a 1-month wash-out period in between.RESULTS:
Liver biochemistry equally improved in both groups. Biliary enrichment (% UDCA of total bile salts, mean +/- SEM) was 40.1 +/- 2.4 in the single dose group vs 40.8 +/- 2.8 in the multiple dose group (p = NS) and was positively correlated with biochemical improvement (AP r = 0.47, p = 0.02; GGT r = 0.58, p = 0.002; ASAT r = 0.67, p = 0.002; ALAT r = 0.52, p = 0.01). Biochemical improvement was not correlated with the concentration or %UDCA in serum. Patients participating in the cross-over design had comparable biochemical response and biliary %UDCA during both regimens.CONCLUSION:
Single and multiple dose UDCA have similar effects on liver biochemistry and biliary enrichment in cholestatic liver disease. Biochemical improvement appears to be related to biliary (but not serum) enrichment with UDCA.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácido Ursodesoxicólico
/
Colagogos y Coleréticos
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Colangitis Esclerosante
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Cirrosis Hepática Biliar
Tipo de estudio:
Clinical_trials
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Diagnostic_studies
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Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Hepatol
Asunto de la revista:
GASTROENTEROLOGIA
Año:
1996
Tipo del documento:
Article
País de afiliación:
Países Bajos