Mapping abnormal synovial vascular permeability in temporomandibular joint arthritis in the rabbit using MRI.
Br J Rheumatol
; 35 Suppl 3: 23-5, 1996 Dec.
Article
en En
| MEDLINE
| ID: mdl-9010085
ABSTRACT
An automated method for two-dimensional spatial depiction (mapping) of quantitative physiological tissue characteristics derived from contrast-enhanced MRI was applied to a model of inflammatory disease represented by antigen-induced arthritis of the temporomandibular joint in the rabbit. Specifically, an established two-compartment kinetic model of unidirectional mass transport was implemented on a pixel-by-pixel basis to generate maps of tissue permeability surface area product (PS) and fractional blood volume (BV) based on dynamic MRI intensity data after administration of albumin-(Gd-DTPA)30, a prototype macromolecular contrast medium designed for blood pool enhancement. Maps of PS and BV in a disease model of induced arthritis clearly depicted zones of increased permeability (up to approximately 200 microliters/cc/h-compared to 25 microliters/cc/h in normal tissues).
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Artritis
/
Membrana Sinovial
/
Articulación Temporomandibular
/
Imagen por Resonancia Magnética
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Br J Rheumatol
Año:
1996
Tipo del documento:
Article
País de afiliación:
Estados Unidos