Congenital absence of the uterus and vagina is not commonly transmitted as a dominant genetic trait: outcomes of surrogate pregnancies.
Fertil Steril
; 67(2): 387-9, 1997 Feb.
Article
en En
| MEDLINE
| ID: mdl-9022619
ABSTRACT
OBJECTIVE:
To determine the inheritance pattern of congenital absence of the uterus and vagina in affected women undergoing surrogacy IVF with this disorder.DESIGN:
Retrospective study.SETTING:
A hospital-based reproductive endocrinology and infertility center. PATIENT(S) Women diagnosed with congenital absence of the uterus and vagina undergoing IVF with subsequent transfer of embryos to a surrogate uterus. INTERVENTION(S) Questionnaires were sent to all infertility treatment centers performing surrogate procedures. MAIN OUTCOME MEASURE(S) Number, gender, and frequency of congenital anomalies in progeny. RESULT(S) Thirty-two of 53 surveyed programs responded (60%). One hundred sixty-two IVF cycles were performed, and 34 liveborn children were delivered (half female). No congenital anomalies were found, except for one male child with a middle ear defect and hearing loss. CONCLUSION(S) These results strongly suggest that congenital absence of the uterus and vagina, if genetically transmitted, is not inherited commonly in a dominant fashion.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Útero
/
Vagina
/
Madres Sustitutas
/
Genes Dominantes
Tipo de estudio:
Etiology_studies
/
Observational_studies
Límite:
Female
/
Humans
/
Male
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
Fertil Steril
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos