Progressive obstructive lung disease associated with microscopic polyangiitis.
Am J Respir Crit Care Med
; 155(2): 739-42, 1997 Feb.
Article
en En
| MEDLINE
| ID: mdl-9032221
ABSTRACT
Small airway involvement and progressive severe airflow obstruction are unexpected features in patients with microscopic polyangiitis. We report the case of a patient with microscopic polyangiitis and circulating anti-neutrophil cytoplasmic antibodies (ANCA), who developed pulmonary hyperinflation and airflow obstruction over a 7-yr period. Systemic manifestations of this vasculitis improved under corticosteriods and cyclophosphamid therapy, a treatment that did not influence either the very high level of anti-myeloperoxidase antibodies or the ventilatory impairment. Small airway involvement was suspected on the basis of pathologic small airway lesions and a mild emphysematous pattern on computed tomography (CT) scan, which was out of proportion with the severity of the obstructive lung disease.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vasculitis
/
Anticuerpos Anticitoplasma de Neutrófilos
/
Enfermedades Pulmonares Obstructivas
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Am J Respir Crit Care Med
Asunto de la revista:
TERAPIA INTENSIVA
Año:
1997
Tipo del documento:
Article
País de afiliación:
Francia