Therapy-related chromosomal changes and cytogenetic heterogeneity in human gliomas.
J Neurooncol
; 32(1): 7-17, 1997 Mar.
Article
en En
| MEDLINE
| ID: mdl-9049858
ABSTRACT
The karyotypes of 18 primary 'untreated' gliomas, 6 recurrent gliomas treated with radiotherapy and/or chemotherapy and 2 gliomas before and after treatment are described, based on observations using standard cytogenetic techniques. In comparison to the untreated gliomas there were relatively consistent chromosome differences in the treated gliomas, including (1) deletions of the long arm of chromosome 7 with breakpoint at q22, possibly induced by alkylating agents, and (2) numerous single cell abnormalities or unrelated clones of structural abnormalities, presumably induced by radiotherapy.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Encefálicas
/
Cromosomas
/
Heterogeneidad Genética
/
Glioma
Límite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Neurooncol
Año:
1997
Tipo del documento:
Article
País de afiliación:
Canadá