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Expression of MAGE genes in esophageal squamous-cell carcinoma.
Quillien, V; Raoul, J L; Heresbach, D; Collet, B; Toujas, L; Brasseur, F.
Afiliación
  • Quillien V; Département die Biologie Clinique, Centre Eugène Marquis, Rennes, France.
Anticancer Res ; 17(1A): 387-91, 1997.
Article en En | MEDLINE | ID: mdl-9066682
The genes MAGE-1, -2, -3 and -4 are expressed in tumors of different histological types, but not in normal tissues, with the exception of testis and placenta. Short peptides derived from MAGE-1 and MAGE-3 gene products are recognized by cytolytic T lymphocytes when presented by HLA-class-I molecules, and represent potential targets for specific immunotherapy. We have determined whether esophageal carcinoma patients should be eligible for MAGE-peptide-based vaccine therapies. The expression of genes MAGE-1, -2, -3 and -4 in tumor samples was assessed by reverse-transcription and polymerase-chain-reaction amplification. Out of the 49 esophageal squa-mous-cell carcinomas studied, 53% expressed MAGE-1, 49% MAGE-2, 47% MAGE-3 and 71% MAGE-4. Eighty-four percent of the tumors expressed one or more of the four MAGE genes. Owing to the high incidence of MAGE gene expression in esophageal squamous-cell carcinoma, a large proportion of patients could be suitable candidates for immune therapies involving tumor-specific antigens encoded by MAGE genes.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Esofágicas / Carcinoma de Células Escamosas / Antígenos de Neoplasias / Proteínas de Neoplasias Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Anticancer Res Año: 1997 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Grecia
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Esofágicas / Carcinoma de Células Escamosas / Antígenos de Neoplasias / Proteínas de Neoplasias Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Anticancer Res Año: 1997 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Grecia