Mouse strain and source of L-tryptophan affects hepatic nuclear tryptophan binding.
Toxicology
; 118(1): 37-47, 1997 Mar 14.
Article
en En
| MEDLINE
| ID: mdl-9074652
ABSTRACT
This study describes that the affinity for specific L-tryptophan binding to hepatic nuclei in vitro is markedly decreased in NZBWF1 mice in comparison to that in Swiss mice. Also, the hepatic nuclei of NZBWF1 mice have a significantly decreased binding response in vitro to Showa Denko L-tryptophan (implicated in the eosinophilia-myalgia syndrome) or to its contaminants, 1,1'-ethylidenebis(tryptophan) or 3-phenylamino-L-alanine, when each is added to control, non-implicated L-tryptophan compared with hepatic nuclei of Swiss mice. Enhanced hepatic protein synthesis induced by tube-feeding control L-tryptophan is much less in NZBWF1 mice than in Swiss mice. Tube-feeding of Showa Denko L-tryptophan induced less stimulation of hepatic protein synthesis than did control L-tryptophan in Swiss mice but essentially none in NZBWF1 mice. NZBWF1 mice have a genetically altered response to L-tryptophan which may prove to be useful is studying the role of L-tryptophan in health and in disease.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Triptófano
/
Hígado
Límite:
Animals
Idioma:
En
Revista:
Toxicology
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
IE
/
IRELAND
/
IRLANDA