Extended clomiphene citrate (CC) and prednisone for the treatment of chronic anovulation resistant to CC alone.
Fertil Steril
; 67(4): 641-3, 1997 Apr.
Article
en En
| MEDLINE
| ID: mdl-9093187
ABSTRACT
OBJECTIVE:
To evaluate effectiveness and safety of a regimen of extended clomiphene citrate (CC) and prednisone for patients who fail treatment with CC alone.DESIGN:
Retrospective observational analysis.SETTING:
University-based tertiary infertility center. PATIENT(S) Twenty-four anovulatory patients who failed to ovulate after CC 150 mg administered for 5 days. INTERVENTION(S) Treatment consisted of CC given on cycle days 3 through 9 (extended) at a starting dose of 100 to 150 mg/d. Additionally, patients were given prednisone 5 mg orally each night throughout the cycle. MAIN OUTCOME MEASURE(S) Ovulation was confirmed by luteal serum P. Pregnancy was confirmed by rising hCG levels and transvaginal ultrasound. RESULT(S) A total of 60 cycles were available for review. Forty-four of these cycles were ovulatory (73%) and 11 patients (46%) conceived on this therapy. Logistic (two-parameter) pregnancy occurrence over time (cycles) revealed a maximum pregnancy probability of 0.66 and a cycle fecundity of 0.36. No complications of therapy were noted. CONCLUSION(S) Clomiphene citrate-resistant anovulatory patients have high rates of ovulation and pregnancy after treatment with extended CC and prednisone. This therapy offers a potential reduction in cost and risk and should be considered in this group of patients before gonadotropin stimulation or surgery.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Prednisona
/
Clomifeno
/
Fármacos para la Fertilidad Femenina
/
Glucocorticoides
/
Anovulación
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Fertil Steril
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos