Cobalt-55 positron emission tomography in ischemic stroke.
Clin Neurol Neurosurg
; 99(1): 6-10, 1997 Feb.
Article
en En
| MEDLINE
| ID: mdl-9107460
ABSTRACT
After acute cerebral stroke, the (peri-) infarct tissue is characterized by calcium (Ca)-mediated neuronal damage and inflammatory processes. Monitoring Ca-mediated damage using the isotope cobalt-55 (Co) as a Ca-tracer may enable PET-imaging of this tissue. Since the fate of (peri-) infarct tissue determines clinical outcome, Co-PET may have prognostic value in stroke. Six stroke patients were examined with Co-PET, MRI and a middle cerebral artery (mca) stroke scale (Orgogozo). In every patient, specific Co-accumulation in the appropriate brain region was seen, irrespective of the integrity of the blood-brain barrier. This pilot study suggests Co-PET as a diagnostic tool in stroke, which may provide additional information on the clinical outcome. Validation of method in larger patient series is necessary.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Daño Encefálico Crónico
/
Canales de Calcio
/
Tomografía Computarizada de Emisión
/
Infarto Cerebral
/
Radioisótopos de Cobalto
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Neurol Neurosurg
Año:
1997
Tipo del documento:
Article
País de afiliación:
Países Bajos