Involvement of cytokines in cachexia induced by T-cell leukaemia in the rat.
Eur Cytokine Netw
; 8(1): 45-9, 1997 Mar.
Article
en En
| MEDLINE
| ID: mdl-9110147
ABSTRACT
The objective of this study was to investigate the involvement of cytokines (IL-1, IL-6 and TNF-alpha) in cachexia induced by T-cell leukaemia in the rat. Leukaemic rats exhibited a marked and significant increase in circulating IL-6 concentration from days 12-17 corresponding to the period of weight loss after induction of leukaemia. IL-6 plasma bioactivity correlated significantly with spleen weight and weight loss, implicating IL-6 in the cachectic response. In contrast, IL-1 and TNF-alpha plasma bioactivities were not increased compared to control rats, indicating that these cytokines are not circulating mediators of cachexia induced by T-cell leukaemia in the rat. These data suggest that IL-6 produced by the host may contribute to cachexia induced by T-cell leukaemia.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Caquexia
/
Leucemia de Células T
/
Interleucina-6
/
Interleucina-1
/
Factor de Necrosis Tumoral alfa
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Eur Cytokine Netw
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
1997
Tipo del documento:
Article
País de afiliación:
Reino Unido